Examples

莫大的侮辱

a gross insult

视为莫大光荣

regard as a great honour

她受到了莫大的冤屈，却有口难辩。

She is suffering a huge injustice, but finds it hard to defend herself.

莫大的讽刺。

Being sacked was the final humiliation.

被解雇是莫大的羞辱。